circulating levels of omentin-1 in patients with breast cancer

background: it seems adipocytokines play an important role in breast cancer. omentin-1 is a novel discovered plasma adipocytokine produced mainly in visceral adipose tissue. the aim of present study was to estimate. circulating levels of omentin-1 in postmenopausal breast cancer patients as compare to healthy postmenopausal subjects. materials and methods: this study consisted of 30 postmenopausal women with newly diagnosed breast cancer and 30 healthy postmenopausal subjects aged 45 to 70 years. serum levels of omentin-1 were measured by enzyme-linked immunosorbent assay. results: the mean age of the case group was 54.3±8.3 years, and the control group was 50.3±3.2 years. the mean serum levels of omentin-1 in the case group were 73.1±29.7 ng/ml and in the control group were 108.8±65.4 ng/ml. the mean serum omentin-1 levels were found to be significantly lower in breast cancer patients (p=0.009). we also demonstrated the negative correlation of omentin-1 with bmi in both groups (p=0.005), however, we did not find any association between age and serum omentin-1 levels (p=ns). conclusion: our studied showed that omentin-1 level was significantly reduced in the breast cancer patients as compare to healthy controls. decreased omentin-1 levels may contribute to the development of cancer, however determination of its role and mechanisms needs more investigations. to sum up, our data suggest that omentin-1 can be used as a marker for early detection of breast cancer in postmenopausal women. k e y w o r ds: breast cancer, omentin, serum